Current-dependent block of endplate channels by guanidine derivatives.
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چکیده
منابع مشابه
Current-dependent block of endplate channels by guanidine derivatives
Methyl- and ethylguanidine block the endplate current in frog muscle. Both derivatives blocked inward-going endplate currents without affecting outward endplate currents. Repetitive stimulation that evoked several inward endplate currents enhanced the block, which suggests that these agents interact with open endplate channels. The relative conductance vs. potential curve exhibited a transition...
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The effects of the n-alkyl derivatives of guanidine on the frog neuromuscular junction were studied using the two-microelectrode voltage clamp and other electrophysiological techniques. Methyl-, ethyl-, and propylguanidine stimulated the nerve-evoked release of transmitter. However, amyl-and octylguanidine had no apparent presynaptic action. All of the derivatives blocked the postsynaptic respo...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1984
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.83.6.901